Title list by research areas [The University of Osaka Biomedical R&D Seeds 2024]

• Drugs (Cancer)
• Drugs (Brain and Psychiatry)
• Drugs (Intractable diseases)
• Drugs (Cardiovascular diseases)
• Drugs (Infectious diseases)
• Drugs (Others)
• Medical devices
• Regenerative medicine
• Diagnostics

Drugs (Cancer)

• Development of the new anti-cancer medicine targeting GREB1, a novel Wnt signal-related molecule (Center for Infectious Disease Education and Research, Specially Appointed Professor Akira KIKUCHI, Department of Molecular Biology & Biochemistry, Graduate School of Medicine, Associate Professor Shinji MATSUMOTO)
• Research and development of intellectual property for epigenomic drug discovery that dually targets cancer stem cells and cancer immunity (Department of Medical Data Science, Graduate School of Medicine, Professor Hideshi ISHII)
• Maximizing cost-effectiveness by conjugating modifications for clinical application of innovative nucleic acid drugs (Department of Medical Data Science, Graduate School of Medicine, Professor Hideshi ISHII)
• Development of novel therapeutic agents for refractory BRAF mutation-positive colorectal cancer (Department of Gastroenterological Surgery, Graduate School of Medicine, Faculty of Medicine Lecturer Hidekazu TAKAHASHI)
• Development of anti-cancer drug targetting CKAP4 (Center for Infectious Disease Education and Research, Specially Appointed Professor Akira KIKUCHI)
• Rapid clinical application of specific inhibitors targeting refractory gastrointestinal cancer stem cells (Department of Medical Data Science, Graduate School of Medicine, Professor Hideshi ISHII)
• Development of Nucleic Acid Lipid Nanoparticles with Anticancer Effects (Research Institute for Microbial Diseases, Guest Professor, Graduate School of Biomedical Sciences, Nagasaki University, Professor Taiki AOSHI)
• Innovative alpha therapy targeting PSMA for refractory prostate cancer (Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Assistant Professor Tadashi WATABE)
• Targeted alpha-ray therapy for refractory thyroid cancer (Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Assistant Professor Tadashi WATABE)
• Development of a new treatment for chemotherapy-resistant triple-negative breast cancer (Department of Advanced Molecular Therapy, Graduate School of Medicine, Professor Yoshiaki TANIYAMA)

Drugs (Brain and Psychiatry)

• Development of therapeutic agents for amyotrophic lateral sclerosis by improving ribosome function (Department of Neurotherapeutics, Graduate School of Medicine, Professor Seiichi NAGANO)
• Development of ASOs for multiple system atrophy (Department of Neurology, Graduate school of Medicine, Assistant Professor Yasuyoshi KIMURA, Professor Hideki MOCHIZUKI)

Drugs (Intractable diseases)

• Region-specific LOH-inducing applied to HLA region and the sensitive region extracted by GWAS (Genome Editing Research and Development Center, Graduate School of Medicine, Assistant professor Yasuhide YOSHIMURA)
• Development of inhibitors of protein phosphatases involved in neurodegenerative diseases and investigation of their effects in animal models (The department of Biological Control, RIMD, Specially Appointed Assistant Professor Shizuka ISHITANI)

Drugs (Cardiovascular diseases)

• Novel therapeutic strategy for cerebral stroke using Npas4-related factors (Graduate school of medicine, Professor Taiichi KATAYAMA, Graduate school of pharmaceutical sciences, Guest Professor Akio TSUBOI)
• Development of First-in-class Drug for Bradyarrhythmia (NTC-801F KACh Channel Inhibitor Phase II clinical trial) (Department of Cardiovascular Medicine, Graduate School of Medicine, Specially Appointed Associate Professor Yoshihiro ASANO)

Drugs (Infectious diseases)

• Development of Reoviridae virus-based mucosal vaccine vector systems (Research Institute for Microbial Diseases, Professor Takeshi KOBAYASHI)
• Clinical Development of NPC-BKSE36/CpG Malaria Vaccine (Department of Malaria Vaccine Development, Research Institute for Microbial Diseases, Endowed Chair Professor Toshihiro HORII)

Drugs (Others)

• Development of single-molecule imaging-based screening technology for drug discovery (Graduate School of Frontier Biosciences, Professor Masahiro UEDA)
• Development of repair therapy for skin barrier function by product lipids of novel lipase (Department of Bio-system Pharmacology, Graduate School of medicine, Associate Professor Ryuichi OHGAKI)
• Establishment of a new strategy for the treatment of functional restoration in skeletal muscle injury by tissue engineering using osteopontinederived SVVYGLR peptide (Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Professor Susumu TANAKA)
• A new anti-inflammatory drug that utilizes the active site of an endogenous NFkB direct inhibitory protein (Department of Obstetrics & Gynecology, Graduate School of Medicine, Guest Associate Professor Kazuki OKAMOTO)

Medical devices

• AI Estimation of the Wall Fragility Site of Cerebral Aneurysm Based on 4D-CTA and 4D-MRA Medical Images and Clinical Application of Head Models (Department of Pure and Applied Mathematics, Graduate School of Information Science and Technology, Professor Yoshie SUGIYAMA)
• Development of a new disinfection device using Pernitric acid solution (Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Associate Professor Katsuhisa KITANO)
• Diamond bur for suppressing heat generation in bone resection (Graduate School of Engineering, Assistant Professor Urara SATAKE)
• Visualization Technology for Disease States Based on Multidimensional Chemical Distribution Information (Department of Physics, Graduate School of Science, Associate Professor Yoichi OTSUKA)
• Raman spectroscopic tissue detection for minimallyinvasive and precise medicine (Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives, Associate Professor Yasuaki KUMAMOTO)
• Construction of the rapid detection system of gut bacterium for health awareness improvement (Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives, Specially Appointed Associate Professor Masato SAITO)
• Development of New Techniques for Wireless EEG Measurement Device with Light Weight and Long Time Operation (Division of Electrical, Electronic and Infocommunications Engineering, Graduate School of Engineering, Associate Professor Daisuke KANEMOTO)
• Novel diagnostic marker to differentiate urogenital carcinoma by chiral amino acids in body fluids (Department of Urology Graduate School of Medicine, Associate Professor (Lecturer) Atsunari KAWASHIMA)
• SPECT system for boron neutron capture therapy (BNCT-SPECT) for real-time measurement of therapeutic effect (Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Professor Isao MURATA)
• Development of an AI system to predict facial morphology after orthodontic treatment (Department of Orthodontics, Osaka University Dental Hospital, Associate Professor (Lecturer) Chihiro TANIKAWA)
• Development of a medical device to visualize abnormalities in the 3D surface morphology of the skull as a color map (Department of Orthodontics, Osaka University Dental Hospital, Associate Professor (Lecturer) Chihiro TANIKAWA)
• Development of “peptide” pulp capping agent promoting wound healing process of pulp tissue (Osaka University Dental Hospital, Associate Professor (Lecturer) Yusuke TAKAHASHI)
• Development of minimally invasive device system for evaluating the prospect of uterine receptivity for each cycle (Department of Obstetrics & Gynecology, Graduate School of Medicine, Professor Tadashi KIMURA)
• Restoration of Motor and Communication by Wireless Implantable Brain Machine Interfaces (Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, Specially Appointed Professor Masayuki HIRATA)
• Research and development of innovative remote cardiac rehabilitation system (Department of Cardiovascular Medicine, Graduate School of Medicine, Professor Yasushi SAKATA, Specially Appointed Researcher Tatsunori TANIGUCHI)

Regenerative medicine

• Repair of incurable meniscal injuries using an aligned electrospun nanofibrous scaffold combined with mesenchymal stem cells (Department of Orthopaedic Surgery, Graduate School of Medicine, Visiting Academic Staff Kazunori SHIMOMURA)
• Development of Meniscus Regeneration Therapy Using Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells and Atelocollagen Meniscus Regeneration Material (Department of Health and Sport Sciences, Medicine for Sports and Performing Arts, Graduate School of Medicine, Professor Ken NAKATA)
• Regeneration therapy using autologous bone marrow derived M2 macrophage for severe heart failure (Osaka University Hospital, Assistant Professor Kizuku YAMASHITA)
• Development of a novel therapy for α-synucleinopathy using regulatory T cells (Department of Neurology, Graduate school of Medicine, Professor Hideki MOCHIZUKI)
• Development of new periodontal tissue regeneration therapy using autologous adipose tissue-derived stem cells (Graduate School of Dentistry, Professor Shinya MURAKAMI, Associate Professor (Lecturer) Masahide TAKEDACHI)

Diagnostics

• Development of a New Method for Detection of Effects Induced by Maternal Immune Activation (Department of Neuroscience and Cell Biology, Graduate School of Medicine, Professor Shoichi SHIMADA)
• Establishment and clinical application of rapid and highly accurate identification method for nontuberculous mycobacteriosis by real-time core genome analysis (Immunology Frontier Research Center, Assistant Professor Kiyoharu FUKUSHIMA)
• Development of pathological periostin measurement device (Department of Advanced Molecular Therapy, Graduate School of Medicine, Professor Yoshiaki TANIYAMA)
• Development of a diagnostic method for patients with chronic inflammatory disease using analysis of sugar chains of IgGs (Department of Biopathological Information Science, Graduate School of Medicine, Professor Eiji MIYOSHI)

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